Mepivacaine versus bupivacaine spinal anesthesia for return of motor function following total knee arthroplasty: a randomized controlled trial
Authors' conclusion
Although mepivacaine expedited return of motor function after knee arthroplasty, a clinically relevant 20% reduction was not observed. Ambulation times and same-day discharge rates did not differ.
Study context
- Population
- Patients undergoing primary total knee arthroplasty
- Participants
- 163 patients
- Comparison
- Spinal mepivacaine vs isobaric bupivacaine
- Primary endpoint
- Time to return of motor function
Primary result
As reported in the abstract
P < 0.001
Further findings
Pain scores in PACU
P < 0.001
Pain scores in PACU
- No differences in pain scores at 6, 24, or 48 h postoperative
Opioid consumption
- Did not differ at any time point
- P = 0.769
Time to and distance at first ambulation, same-day discharge rate, LOS
- No differences between groups
Safety
Urinary retention
P = 0.007
Nausea, vomiting, pruritus, transient neurological symptoms
- No differences between groups
Original publication
Mepivacaine versus bupivacaine spinal anesthesia for return of motor function following total knee arthroplasty: a randomized controlled trial. Reg Anesth Pain Med. Published 1 May 2025. doi:10.
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