Respiratory failure & ventilation
Methods for determining optimal positive end-expiratory pressure in patients undergoing invasive mechanical ventilation: a scoping review
Authors' conclusion
Numerous methods of determining optimal PEEP have been evaluated; however, notable gaps remain in the evidence supporting their use.
Study context
- Population
- Adults undergoing invasive mechanical ventilation
- Participants
- 17,205 adults · 271 studies
- Outcome
- Methods of determining optimal positive end-expiratory pressure (PEEP) studied
Main finding
As reported in the abstract
- Methods identified
- 22
- Methods studied with an RCT
- 11
- Randomized controlled trials (RCTs) included
- 73
- Patients in RCTs
- 10,733
- Studies in intensive care unit (ICU)
- 216/271, 80%
- Studies in operating room
- 55/271, 20%
- ICU studies enrolling ARDS patients
- 162/216, 75%
- Compliance (studies, RCTs)
- 73 studies, 29 RCTs
- Imaging-based methods (studies, RCTs)
- 65 studies, 11 RCTs
- PEEP-FIO2 tables (studies, RCTs)
- 52 studies, 20 RCTs
- RCTs assessing feasibility
- 3
Original publication
Methods for determining optimal positive end-expiratory pressure in patients undergoing invasive mechanical ventilation: a scoping review. Can J Anaesth. Published 20 November 2024. doi:10.
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