Mortality in patients with septic cardiomyopathy identified by longitudinal strain by speckle tracking echocardiography: An updated systematic review and meta-analysis with trial sequential analysis
Authors' conclusion
We confirmed that more negative LS values are associated with higher survival in septic patients.
Study context
- Population
- Septic patients with left ventricular (LV) longitudinal strain measured (global or regional) by speckle tracking echocardiography
- Participants
- 1,678 patients · 14 studies
- Comparison
- LV longitudinal strain in survivors vs non-survivors
- Outcome
- Association between LV longitudinal strain (LS) and survival
Methodological detailstrial sequential analysis, sensitivity analyses
- Trial sequential analysis
- Sensitivity analyses
Pooled result
As reported in the abstract
- Better performance (more negative longitudinal strain (LS)) associated with survival, MD (%)
- −1.45%[−2.10, −0.80]
- P value
- p < 0.0001
- Heterogeneity I2
- I2 = 42%
Further pooled results
Subgroups by number of views for LS, sepsis severity, sepsis criteria (subgroup)
- No subgroup differences: number of views used to calculate LS
- P = 0.31
- No subgroup differences: severity of sepsis
- P = 0.42
- No subgroup differences: sepsis criteria
- P = 0.59
Association between LVEF and survival
- Higher LVEF associated with survival, MD (%)
- 2.44% [0.44,4.45]
- P value
- P = 0.02
- Heterogeneity I2
- I2 = 42%
- 13 studies reported LVEF
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mortality in patients with septic cardiomyopathy identified by longitudinal strain by speckle tracking echocardiography: An updated systematic review and meta-analysis with trial sequential analysis. Anaesth Crit Care Pain Med. Published 19 December 2023. doi:10.
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