Cardiothoracic & vascular anesthesia
Nociception level index response to pacemaker stimulation
Authors' conclusion
The NOL index captured the studied nociception-antinociception balance during pacemaker stimulation when recalibrated to the paced rate.
Study context
- Population
- Mechanically ventilated adults after elective cardiac surgery, without nociceptive inputanalysed
- Participants
- 20 participants
- Exposure
- Pacing at 90 and 110 beats min- 1 vs baseline
- Outcome
- NOL index response to pacemaker stimulation (pacing at 90 and 110 beats min- 1, washout, rechallenge, recalibration) vs baseline, in the absence of nociceptive input
- Follow-up
- Last minute of each period
Methodological detailsrepeated measures, within-patient pacing protocol
- Repeated measures
- Within-patient pacing protocol
Main finding
As reported in the abstract
Baseline
2.1
least-square adjusted mean · SE 1.74
Pacing 90
8.4
least-square adjusted mean · SE 1.73
Pacing 110
18.4
least-square adjusted mean · SE 1.73
Washout
1.1
least-square adjusted mean · SE 1.73
Rechallenge
18.0
least-square adjusted mean · SE 1.73
Recalibration
1.1
least-square adjusted mean · SE 1.73
Continued monitoring
1.5
least-square adjusted mean · SE 1.73
Pacing 90 vs Baseline: P = 1.000 · Pacing 110 vs Baseline: P < 0.001 · Washout vs Baseline: P = 1.000 · Rechallenge vs Baseline: P < 0.001 · Recalibration vs Baseline: P = 1.000 · Continued monitoring vs Baseline: P = 1.000
- Pacemaker-induced HR changes significantly affected Nociception Level (NOL) over time (F = 28.420)
- P < 0.001
Observational data: associations, not effects.
Original publication
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