One-year outcomes in sepsis: a prospective multicenter cohort study in Japan
An erratum to this article was published (J Intensive Care, 22 May 2025 ↗)
Authors' conclusion
This multicenter study identified the distinct realities of post-sepsis life in Japanese ICU patients, highlighting the unique challenges in improving their functions and returning to daily life.
Study context
- Population
- Consecutive adult intensive care units (ICU) patients diagnosed with sepsis (Sepsis 3) at ICU admission, Japan, Nov 2020–Apr 2022
- Participants
- 339 patients
- Outcome
- Death or PICS (Barthel Index ≤ 90, Short Memory Questionnaire < 40, HADS anxiety or depression subscale ≥ 8, or Impact of Event Scale-Revised ≥ 25)
- Follow-up
- 3, 6 and 12 months after hospital discharge
Methodological detailsmulticentre, 21 ICUs in 20 tertiary hospitals, Follow-up by telephone and mail
- Multicentre
- 21 ICUs in 20 tertiary hospitals
- Follow-up by telephone and mail
Main finding
As reported in the abstract
Death or PICS incidence · 3, 6 and 12 months
Death or post-intensive care syndrome (PICS) at 3 months
73%
Death or PICS at 6 months
64%
Death or PICS at 12 months
65%
Death or PICS at hospital discharge
89%
Observational data: associations, not effects.
Secondary outcomes
Mortality
- At hospital discharge
- 23%
- At 12 months
- 37%
Quality of Life (QOL), employment and service use over the first year
- Return to work
- 44%
- Hospital readmissions
- 40%
- Emergency service usage
- 31%
- Rehabilitation service use
- 15%
- Psychiatric service use
- 7%
- Limited improvement in QOL
Predictors of PICS-related dysfunction (multivariable analysis)
- Any PICS-related dysfunction consistently an independent factor for the same dysfunction at following follow-ups
Original publication
One-year outcomes in sepsis: a prospective multicenter cohort study in Japan. J Intensive Care. Published 1 May 2025. doi:10.
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