Respiratory failure & ventilation
Oxygen-Saturation Targets and Cognitive and Functional Outcomes in Mechanically Ventilated Adults
Authors' conclusion
Among mechanically ventilated critically ill adults who completed follow-up at 12 months, oxygen-saturation targets were not associated with cognition or related outcomes.
Study context
- Population
- Mechanically ventilated critically ill adults enrolled in the PILOT trialcompleted follow-up
- Participants
- 501 participants
- Comparison
- Lower vs intermediate vs higher oxygen-saturation targets
- Lowern = 142
- Intermediaten = 186
- Highern = 173
- Primary endpoint
- Global cognition (Telephone Montreal Cognitive Assessment)
- Follow-up
- 12 months
Methodological detailsblinded outcome assessment
- Blinded outcome assessment
Primary result
As reported in the abstract
Telephone Montreal Cognitive Assessment score
Adjusted odds ratio (95% CI)
Lower vs Intermediate
1.36(0.92–2.00)
Intermediate vs Higher
0.90(0.62–1.29)
Higher vs Lower
1.22(0.83–1.79)
Further findings
Median
| Outcome | Lower | Intermediate | Higher |
|---|---|---|---|
| Achieved SpO2 | 94% (IQR 91–96%) | 95% (IQR 93–97%) | 97% (IQR 95–99%) |
Individual cognitive domains, disability, employment, quality of life · 12 months
- No difference between target groups
Original publication
Oxygen-Saturation Targets and Cognitive and Functional Outcomes in Mechanically Ventilated Adults. Am J Respir Crit Care Med. Published 1 April 2024. doi:10.
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