Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study
Authors' conclusion
In this study, long-term immunosuppressive therapy excluding chemotherapy was not associated with significantly higher or lower ICU and 3-month mortality in patients admitted to the ICU for septic shock.
Study context
- Population
- Patients admitted to the intensive care unit (ICU) for septic shock, 8 high-enroller centres
- Participants
- 433 patients
- Exposure
- Long-term immunosuppressive therapy vs none
- Exposedn = 103
- Non-exposedn = 330reference
- Outcome
- ICU mortality
Methodological detailsmulticentre, multivariate logistic regression, Reason for immunosuppression: organ transplantation n = 45 [44%], systemic disease n = 58 [56%]
- Multicentre
- Multivariate logistic regression
- Reason for immunosuppression: organ transplantation n = 45 [44%], systemic disease n = 58 [56%]
Main finding
As reported in the abstract
exposed vs non-exposedOdds ratio (95% CI)P value
Univariate
0.95(0.56–1.58)
P = 0.86Multivariate
1.13(0.61–2.05)
P = 0.69Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| 3-month mortality · 3 monthsExposed vs non-exposed · univariate | 1.13 (0.69–1.82) | P = 0.62 | |
| 3-month mortality · 3 monthsExposed vs non-exposed · multivariate | 1.36 (0.78–2.37) | P = 0.28 | |
| 0.512Odds ratio (log scale) |
Original publication
Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study. Crit Care. Published 2 September 2023. doi:10.
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