Cardiothoracic & vascular anesthesia
Perioperative Implementation of Low-Dose Pregabalin in an Enhanced Recovery After Cardiac Surgery Protocol: A Pre-Post Observational Study
Authors' conclusion
In this evaluation of perioperative pregabalin administration for patients requiring cardiac surgery, pregabalin reduced postoperative opioid use, with significant reductions on postoperative day 0, and without any significant increase in adverse reactions. However, no differences in intensive care unit length of stay, time to extubation, or mortality were noted.
Study context
- Population
- Patients undergoing off-pump CABG within an ERAS after cardiac surgery protocol, tertiary care hospital
- Exposure
- Pregabalin 75 mg BID for 48 hours postoperatively vs no pregabalin
- Outcome
- Opioid consumption (morphine milligram equivalents (MME))
- Follow-up
- POD 0
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Reduction
30.6%
P < 0.001
By group
Observational data: associations, not effects.
Further findings
Median
| Outcome | Pregabalin | Control | P value |
|---|---|---|---|
| Pain scores, 0-to-12 hoursGreater pain scores with pregabalin | 3.32 (IQR 1.65–4.36) | 2.0 (IQR 0–3.25) | P = 0.013 |
Pain scores, POD 1–4
- No significant difference POD 1
- P = 0.492
- No significant difference POD 2
- P = 0.442
- No significant difference POD 3
- P = 0.237
- No significant difference POD 4
- P = 0.649
Average RASS score
- Not statistically significant at 12 hours
- P = 0.954
- Not statistically significant at 24 hours
- P = 0.301
ICU LOS, time to extubation, mortality
- No significant differences between groups
Safety
Adverse events
- No increased incidence with pregabalin
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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