Anaesthetic drugs & techniques
Perioperative intravenous lidocaine plus esketamine and patient-reported recovery after functional endoscopic sinus surgery
Primary result · QoR-40 total scoreResult — go to the resultAdjusted mean difference 10.5 95% CI 5.7–15.3Authors' conclusion
In this secondary analysis, perioperative lidocaine plus esketamine during FESS was associated with higher QoR-40-assessed patient-reported recovery on POD1 and POD2, lower early anxiety/depression symptom scores, and lower postoperative inflammatory biomarkers.
Study context
- Population
- Adults (18–65 years) undergoing functional endoscopic sinus surgery (FESS)137/140 analysed at POD1
- Participants
- 140 adults
- Comparison
- LA vs N
- LAn = 35
- Ln = 35
- An = 35
- Nn = 35reference
- Primary endpoint
- QoR-40 total score (first assessment 24 ± 6 h after extubation)
- Follow-up
- POD1
Methodological detailssingle-centre, four-arm
- Single-centre
- Four-arm
Primary result
QoR-40 total score
Adjusted mean difference
10.5
95% CI 5.7–15.3
P = 3.36 × 10-5
LA vs N
adjusted mean difference 10.5 (95% CI 5.7–15.3); P = 3.36 × 10-5
As reported in the abstract
Secondary outcomes
| Outcome | Adjusted mean difference (95% CI) | P value | |
|---|---|---|---|
| QoR-40 total score (key secondary endpoint) · POD2LA vs N | 8.2 (4.6–11.8) | P = 1.56 × 10-5 | |
| −5051015Difference (linear scale) |
| Outcome | LA | N | RR (95% CI) | |
|---|---|---|---|---|
| Emergence agitation (Riker ≥ 5)LA vs N · CI crossed unity | 11.4% | 31.4% | 0.36 (0.13–1.03) | |
| 0.10.31310Relative risk (log scale) |
| Outcome | Estimate |
|---|---|
| IL-6 and TNF-α · 24 h | ratio (IL-6) 0.77 (CI 0.69–0.86) |
| IL-6 and TNF-α · 24 h | ratio (TNF-α) 0.70 (CI 0.64–0.77) |
QoR-40 total and domain scores (exploratory) · POD7
- Directionally favorable but interpreted descriptively
- 136/140 analysed
SAS and SDS scores · POD1
- Lower SAS in LA (points)
- −4.9
- Lower SDS in LA (points)
- −5.7
Safety
| Outcome | LA | A |
|---|---|---|
| Dreams/hallucinations | 17.1% | 14.3% |
Serious drug-related adverse events
- No serious drug-related adverse events occurred
Original publication
Perioperative intravenous lidocaine plus esketamine and patient-reported recovery after functional endoscopic sinus surgery. Perioper Med (Lond). Published 14 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →