Neuroanesthesia & neurocritical care
Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies
Authors' conclusion
Although limited by a small sample size, these data suggest that preoperative covert stroke occurs more commonly than previously anticipated. Plasma neurofilament light is a potential screening biomarker for postoperative ischaemic brain injury.
Study context
- Population
- Participants aged >65 yr undergoing non-intracranial, non-carotid surgery, University of Wisconsin
- Participants
- 58 vs 101
- Comparison
- Postoperative MRI vs Preoperative MRI
- Postoperative MRIn = 58
- Preoperative MRIn = 101reference
- Primary endpoint
- Incidence of preoperative and postoperative (intraoperative or postoperative) covert strokes
Methodological detailspilot study, single-centre
- Pilot study
- Single-centre
Primary result
As reported in the abstract
Incidence of covert stroke (preoperative) and ischaemic brain injury (postoperative)
P = 0.01
Further findings
Peak plasma neurofilament light
P = 0.025
Median
| Outcome | Postoperative brain injury | No brain injury | P value |
|---|---|---|---|
| Pre- vs postoperative brain injury, paired imaging subgroup (n=30) | P = 0.67 | ||
| Delirium severity score | 19 (IQR 17–21) | 7 (IQR 4–12) | P = 0.01 |
Pre- vs postoperative brain injury, paired imaging subgroup (n=30)
- Same effect not identified
Original publication
Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies. Br J Anaesth. Published 24 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →