Perioperative medicine & outcomes
Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study
Authors' conclusion
Perioperative changes in plasma amyloid do not appear to be associated with postoperative delirium. Our findings do not support associations of dynamic changes in amyloid with postoperative delirium.
Study context
- Population
- Participants aged >65 yr undergoing non-intracranial surgery, IPOD-B3 cohort, USA
- Participants
- 100 participants
- Exposure
- Delirium vs no delirium; change in plasma amyloid beta ratio (Aβ42:Aβ40) from preoperative to POD 1
- Outcome
- Delirium severity (Delirium Rating Scale-Revised-98) in relation to change in plasma AβR
Main finding
As reported in the abstract
Peak delirium severity vs change in plasma AβR · POD 1
Log[incidence rate ratio], adjusted for confounders; not associated
0.43
P=0.14
Observational data: associations, not effects.
Further findings
Plasma AβR change, all participants · preoperative to POD 1
- Plasma AβR increased
- Wilcoxon P<0.001
Delirium incidence (3D-CAM) vs AβR increase
- Not associated
- Wilcoxon P=0.22
POD 1 change in plasma tau, neurofilament light, inflammatory markers; operative time; low intraoperative arterial pressure
- Not associated with POD 1 change in plasma AβR
Original publication
Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: Biomarker-3 study. Br J Anaesth. Published 25 February 2023. doi:10.
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