Sevoflurane dose and postoperative delirium: a prospective cohort analysis
Authors' conclusion
Sevoflurane dose was not associated with delirium severity or incidence.
Study context
- Population
- Adults aged >65 yr receiving sevoflurane for non-intracranial surgeryof 167 in cohort
- Participants
- 118 adults
- Exposure
- Sevoflurane dose and delirium
- Outcome
- Delirium severity (Delirium Rating Scale-98)
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Delirium severity
- Correlation with AMS (Spearman's ρ)
- −0.014, P=0.89
- Correlation with AUC-S (ρ)
- 0.093, P=0.35
- AMS, unadjusted log (IRR)
- −0.06 P=0.645
- AMS, adjusted log (IRR)
- −0.0454, P=0.735
- AUC-S, unadjusted log (IRR)
- 0.00, P=0.054
- AUC-S, adjusted log (IRR)
- 0.00, P=0.832
Observational data: associations, not effects.
Further findings
Delirium incidence (3D-CAM or CAM-ICU)
- AMS (Wilcoxon)
- P = 0.86
- AUC-S
- P = 0.78
Sensitivity analyses including propofol dose
- No relationship
Delirium biomarkers (interleukin-8, neurofilament light, total tau, S100B)
- No association with anaesthetic dose
- P > 0.05
Original publication
Sevoflurane dose and postoperative delirium: a prospective cohort analysis. Br J Anaesth. Published 1 October 2022. doi:10.
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