Perioperative medicine & outcomes
Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function
Authors' conclusion
Delayed resolution of inflammation is associated with cognitive impairment after surgery.
Study context
- Population
- Patients aged ≥65 yr undergoing major surgery
- Participants
- 170 patients
- Outcome
- Association of changes in plasma interleukin-6 levels with changes in Trail Making Test B (executive function)
- Follow-up
- 1 yr
Methodological detailsmixed-effects analyses, generalised additive model
- Mixed-effects analyses
- Generalised additive model
Main finding
As reported in the abstract
Changes in interleukin-6 vs changes in Trail Making Test B
- Changes in interleukin-6 associated with changes in Trail Making Test B (generalised additive model), β
- 0.074
- P
- P<0.001
Observational data: associations, not effects.
Further findings
Trail Making Test A and Controlled Oral Word Association Test
- Changes in interleukin-6 also correlated with changes in Trail Making Test A and Controlled Oral Word Association Test
Binary cognitive decline (>1, >1.5, or >2 SD from baseline) (sensitivity analysis)
- Also associated with interleukin-6 changes
Original publication
Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Br J Anaesth. Published 27 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →