Respiratory failure & ventilation
Peripheral intravenous waveform analysis for evaluating volume status in healthy volunteers and mechanically ventilated patients
Main finding · PIVAF1Result — go to the resultChange per LBNP level (log(e)-transformed) −0.11 95% CI −0.14 to −0.09Authors' conclusion
We found statistically significant reductions in PIVAF1 during simulated blood loss but PIVAF1 did not predict increasing stroke volume during head-down tilt in general anesthesia.
Study context
- Population
- Healthy volunteers and mechanically ventilated patients undergoing laparoscopic surgery
- Participants
- 15 vs 20
- Comparison
- PIVAF1 changes during simulated blood loss and head-down tilt under general anesthesia (GA)
- Lower body negative pressure (LBNP)-cohortn = 15
- GA-cohortn = 20
- Outcome
- Change in PIVA-derived fundamental frequency amplitude (PIVAF1) with volume changes
Methodological detailstwo cohorts
- Two cohorts
Main finding
PIVAF1
Change per LBNP level (log(e)-transformed)
−0.11
95% CI −0.14 to −0.09
P < 0.001
By group
GA-cohort
0.71
AUC for predicting 10% change in stroke volume with head-down tilt
LBNP-cohort
change per LBNP level (log(e)-transformed) −0.11 (95% CI −0.14 to −0.09); P < 0.001
As reported in the abstract
Original publication
Peripheral intravenous waveform analysis for evaluating volume status in healthy volunteers and mechanically ventilated patients. J Clin Monit Comput. Published 29 January 2026. doi:10.
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