Cardiothoracic & vascular anesthesia
Persistent critical illness and long-term survival in cardiac surgery: A multicentre cohort study
Main finding · Survival time up to 4 years after ICU admissionResult — go to the resultHR, event not clear (associated with shorter survival times) 3.14 95% CI 2.77–3.55Authors' conclusion
PerCI was associated with poorer outcomes, and this persisted during longer-term follow-up.
Study context
- Population
- Adults (≥16 years) admitted to 83 intensive care unit (ICUs) in Australia and New Zealand after cardiac surgery (CABG, valvular replacement, or both), ANZICS Adult Patient Database, 2018–2022 (Australia) / 2020 (New Zealand)90.8% elective, 9.2% emergent
- Participants
- 73,462 adults
- Exposure
- Persistent critical illness (PerCI) vs no PerCI
- PerCIn = 5,087
- Outcome
- Survival time up to 4 years after ICU admission
- Follow-up
- Up to 4 years
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
HR, event not clear (associated with shorter survival times)
3.14
95% CI 2.77–3.55
Events by group
PerCI
6.9%
5,087
PerCI vs No PerCI
HR, event not clear (associated with shorter survival times) 3.14 (95% CI 2.77–3.55)
Observational data: associations, not effects.
Further findings
Survival time by age (subgroup)
| Estimate | ||
|---|---|---|
| PerCI (patients aged <65 years) | HR, event not clear (larger reductions in survival times) 5.61 (95% CI 4.72–6.67) | |
| PerCI (patients ≥65 years) | HR, event not clear 2.83 (95% CI 2.48–3.23) | |
| 0.10.31310Ratio (log scale) |
- Survival time by age (subgroup): p-interaction <0.0001
Survival time by surgery type and by elective vs emergent surgery (subgroup)
- No significant differences amongst surgery types, or between elective and emergent surgeries
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Persistent critical illness and long-term survival in cardiac surgery: A multicentre cohort study. Anaesth Crit Care Pain Med. Published 9 July 2025. doi:10.
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