Cardiothoracic & vascular anesthesia
Pharmacokinetics of dexmedetomidine in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass
Authors' conclusion
When cardiopulmonary bypass is applied, the plasma concentration of dexmedetomidine decreases due to an increase in the volume of distribution
Study context
- Population
- Infants and small children undergoing cardiac surgery with CPB29 children analysed
- Participants
- 30 infants
- Outcome
- Population pharmacokinetics of dexmedetomidine
Methodological detailsNONMEM modelling, theory-based allometric scaling with fixed exponents, Dexmedetomidine 1 μg/kg over 10 min, then 0.5 μg/kg/h during surgery; 1 μg/kg over 5 min at CPB initiation
- NONMEM modelling
- Theory-based allometric scaling with fixed exponents
- Dexmedetomidine 1 μg/kg over 10 min, then 0.5 μg/kg/h during surgery; 1 μg/kg over 5 min at CPB initiation
Main finding
As reported in the abstract
Dexmedetomidine PK parameter estimates (95% CI), standardized to 70-kg person
- V1 (L)
- 31.6 (17.9-39.5)
- V2 (L)
- 90.1 (44.0-330)
- Cl (L/min)
- 1.08 (0.70-1.25)
- Q (L/min)
- 2.0 (1.05-3.46)
- Volume of third compartment associated with CPB (L)
- 39.4 (19.3-50.9)
Original publication
Pharmacokinetics of dexmedetomidine in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. Paediatr Anaesth. Published 16 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →