Cardiothoracic & vascular anesthesia
Acetaminophen pharmacokinetics in infants and children with congenital heart disease
Authors' conclusion
Acetaminophen pharmacokinetics were characterized using a 2-compartment model with first-order elimination following cardiac bypass surgery in children. Population pharmacokinetic parameter estimates were similar to other studies in children. No differences were detected between patients with cyanotic and acyanotic heart disease.
Study context
- Population
- Children (2–6 years, 9–23 kg) with congenital heart disease after surgery using CPB, single IV acetaminophen 15 mg/kg at start of sternal closure208 concentrations
- Participants
- 30 children
- Exposure
- Cyanotic vs acyanotic congenital heart disease
- Cyanoticn = 15
- Acyanoticn = 15reference
- Outcome
- Acetaminophen PK parameters (clearance and volumes) and differences between cyanotic and acyanotic patients
Methodological detailspopulation PK (non-linear mixed effects models), allometric scaling to 70 kg
- Population PK (non-linear mixed effects models)
- Allometric scaling to 70 kg
Main finding
As reported in the abstract
Clearance CL, L.h-1.70 kg-1
15.3
PPV 22.2%; 95% CI 13.8–16.7
Intercompartment clearance Q, L.h-1.70 kg-1
45.4
PPV 22.4%; 95% CI 25.2–61.9
Central volume of distribution V1, L.70 kg-1
33.5
PPV 23.2%; 95% CI 25.9–38.8
Peripheral volume of distribution V2, L.70 kg-1
32.1
PPV 21.7%; 95% CI 25.9–38.8
Observational data: associations, not effects.
Original publication
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