Plasma copper and endothelial injury markers in sepsis: A prospective observational study
Authors' conclusion
Plasma Cu was associated with endothelial injury markers, inflammatory markers, illness severity, and 28-day mortality in patients with sepsis. However, Cu was not an independent predictor of mortality after adjustment.
Study context
- Population
- ICU patients with sepsis, March–December 2025
- Participants
- 100 patients
- Exposure
- Non-survivors vs survivors at 28 days
- Outcome
- Association of plasma Cu (within 24 h of admission) with endothelial injury markers (VE-cadherin, SDC-1), inflammatory burden, illness severity and mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
Plasma Cu and endothelial injury markers
- Plasma Cu markedly elevated in non-survivors vs survivors
- Higher plasma VE-cadherin and SDC-1 in non-survivors
- Plasma Cu positively correlated with VE-cadherin, SDC-1, APACHE II, SOFA, PCT and CRP; correlations with PCT or CRP weak
Observational data: associations, not effects.
Further findings
Discrimination for 28-day mortality (ROC)
- Plasma Cu moderate discriminatory ability; PCT and CRP no discriminatory ability
Independent association with 28-day mortality (multivariable logistic regression and sensitivity analyses)
- Plasma Cu not independently associated with 28-day mortality after adjustment for illness severity, lactate or inflammatory burden
Original publication
Plasma copper and endothelial injury markers in sepsis: A prospective observational study. J Crit Care. Published 24 September 2026. doi:10.
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