Plasma expansion and renal perfusion in critical COVID‐19 with acute kidney injury (AKI): A prospective case control study
Authors' conclusion
Plasma expansion with a standardized fluid bolus did not increase renal perfusion in critically ill patients with COVID-19, with or without AKI.
Study context
- Population
- ICU-treated critical COVID-19 patients without underlying kidney disease
- Participants
- 9 vs 8
- Exposure
- AKI vs Without AKI
- AKIn = 9
- Without AKIn = 8reference
- Outcome
- Renal perfusion (MRI phase contrast and arterial spin labeling) before and directly after plasma expansion
- Follow-up
- Directly after plasma expansion
Main finding
As reported in the abstract
Total renal and cortical perfusion
- Total renal perfusion and cortical perfusion not significantly changed by plasma expansion in either group
Observational data: associations, not effects.
Further findings
MAP increase after plasma expansion
Medullary perfusion, without AKI
- Medullary perfusion before plasma expansion, without AKI
- 55 (mL/min/100 g; 95% CI 39-79)
- Medullary perfusion after plasma expansion, without AKI
- 34 (mL/min/100 g; 95% CI 24-48)
- Reduction, P
- P = 0.0027
MAP increase after plasma expansion
- Hemodynamic response to plasma expansion similar in both groups
Original publication
Plasma expansion and renal perfusion in critical COVID‐19 with AKI: A prospective case control study. Acta Anaesthesiol Scand. Published 23 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →