Respiratory failure & ventilation
Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure
Authors' conclusion
Plasma sST2 levels independently predict outcomes in ARF and are strongly associated with extrapulmonary organ dysfunction. The weak correlation between plasma and LRT sST2 levels suggests a predominantly systemic source.
Study context
- Population
- Patients with acute respiratory failure (ARF) of diverse etiologies, multicentre cohorts
- Participants
- 1,432 patients · 5 cohorts
- Exposure
- Non-COVID vs COVID-19 ARF; plasma vs lower respiratory tract (LRT) Soluble ST2 (sST2)
- Non-COVIDn = 863
- COVID-19n = 569reference
- Outcome
- Plasma sST2: distribution, organ dysfunction and 30-day mortality
Methodological detailsmulticentre, five cohorts
- Multicentre
- Five cohorts
Main finding
As reported in the abstract
Plasma sST2 markedly elevated vs LRT levels, with weak intercompartmental correlation
> 19-fold
Observational data: associations, not effects.
Further findings
Longitudinal plasma sST2 · first 2 weeks of critical illness
- Nonsurvivors had persistently elevated plasma sST2 vs survivors
Original publication
Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure. Crit Care Med. Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →