Plasma Nitric Oxide Consumption Is Elevated and Associated With Adverse Outcomes in Critically Ill Patients
Authors' conclusion
Plasma NO consumption is elevated in critically ill patients and independently associated with sepsis, ARDS, shock, and hospital death.
Study context
- Population
- Critically ill adults in ICUs of an academic medical center, and healthy controls
- Exposure
- Critically ill vs Healthy controls
- Critically illn = Three hundred sixty-two
- Healthy controlsn = 46reference
- Outcome
- Plasma NO consumption (µM), measured by reductive chemiluminescence
Methodological detailssingle academic medical centre
- Single academic medical centre
Main finding
As reported in the abstract
Plasma NO consumption
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Plasma NO consumption, septic vs nonsepticSignificant in multivariable analyses | Septic mean 4.1 (95% CI 3.8–4.3) µM · Nonseptic mean 3.6 (95% CI 3.3–3.8) µM |
| Plasma NO consumption, ARDS vs non-ARDSSignificant in multivariable analyses | ARDS mean 4.4 (95% CI 4.0–4.9) µM · Non-ARDS mean 3.7 (95% CI 3.6–3.9) µM |
| Plasma NO consumption, shock vs nonshockSignificant in multivariable analyses | Shock mean 4.4 (95% CI 4.0–4.8) µM · Nonshock mean 3.6 (95% CI 3.4–3.8) µM |
| Plasma NO consumption, hospital nonsurvivors vs survivorsSignificant in multivariable analyses | Nonsurvivors mean 5.3 (95% CI 4.4–6.4) µM · Survivors mean 3.7 (95% CI 3.6–3.9) µM |
Correlation of plasma cell-free hemoglobin with nitric oxide (NO) consumption
- Weakly correlated
Original publication
Plasma Nitric Oxide Consumption Is Elevated and Associated With Adverse Outcomes in Critically Ill Patients. Crit Care Med. Published 21 August 2023. doi:10.
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