Cardiothoracic & vascular anesthesia
Platelet Transfusion After Cardiac Surgery
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.28 99% CI 0.49–3.35Authors' conclusion
Platelet transfusion was not associated with hospital mortality, but it was associated with decreased odds of suspected infection and with shorter ICU and hospital stays.
Study context
- Population
- Consecutive adults undergoing CABG and/or cardiac valvular surgery, US tertiary teaching hospital (MIMIC III and IV databases), 2001–2019
- Participants
- 12,043 adults · 1,046 matched pairs
- Exposure
- Perioperative platelet transfusion vs no platelet transfusion
- Platelet recipientsn = 1,046
- Controlsn = 1,046reference
- Outcome
- In-hospital mortality
Methodological detailssingle-centre, propensity-score matched, 1,621 (13.5%) received apheresis-leukoreduced platelets, median 1.19 units per recipient (IQR: 0.93-1.19), median 1.78 hours (IQR: 0.75-4.25) after intensive care unit (ICU) admission, Pre-transfusion platelet count measured in 1,176 (72.5%), median 120 × 109/L (IQR: 89.0-157.0); only 53 (3.3%) below 50 × 109/L
- Single-centre
- Propensity-score matched
- 1,621 (13.5%) received apheresis-leukoreduced platelets, median 1.19 units per recipient (IQR: 0.93-1.19), median 1.78 hours (IQR: 0.75-4.25) after ICU admission
- Pre-transfusion platelet count measured in 1,176 (72.5%), median 120 × 109/L (IQR: 89.0-157.0); only 53 (3.3%) below 50 × 109/L
Main finding
As reported in the abstract
Odds ratio
1.28
99% CI 0.49–3.35
P = 0.4980
Platelet recipients vs Controls
OR 1.28 (99% CI 0.49–3.35); P = 0.4980
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Platelet Transfusion After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 17 December 2022. doi:10.
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