Cardiothoracic & vascular anesthesia
Post–Ex Vivo Lung Perfusion Hypothermic Storage Limits Inflammation and Endothelial Dysfunction
Authors' conclusion
Our findings suggest that post-EVLP hypothermic storage may contribute to mitigating inflammatory responses and endothelial dysfunction prior to transplantation.
Study context
- Population
- Donor lungs assessed by ex vivo lung perfusion (EVLP), single university hospital
- Participants
- 20 donor lungs
- Exposure
- Biomarker concentrations at declamping of the second implanted lung (after post-EVLP hypothermic storage) vs the first, and at end of EVLP
- Outcome
- Inflammatory and endothelial biomarkers after post-EVLP hypothermic storage vs first graft
Methodological detailssingle-centre, consecutive donor lungs
- Single-centre
- Consecutive donor lungs
Main finding
As reported in the abstract
- IL-10 increased
- p = 0.049
- TNF-α increased
- p = 0.030
Observational data: associations, not effects.
Further findings
Association of biomarker variations (post-EVLP hypothermic storage) with grade 3 primary graft dysfunction · 72 hours
- IL-8 positively associated
- R² = 0.56, p = 0.0062
- TNF-α positively associated
- R² = 0.61, p = 0.0039
- ET-1 positively associated
- R² = 0.43, p = 0.01
Biomarker changes during EVLP
- IL-1β elevated
- P = 0.037
- IL-6 elevated
- P = 0.0009
- IL-8 elevated
- P < 0.0001
- IL-10 elevated
- P < 0.0001
- TNF-α elevated
- P < 0.0001
- ET-1 elevated
- P = 0.01
- HS and SD-1 undetected
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Post–Ex Vivo Lung Perfusion Hypothermic Storage Limits Inflammation and Endothelial Dysfunction. J Cardiothorac Vasc Anesth. Published 8 July 2025. doi:10.
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