Respiratory failure & ventilation
Post-extubation polyuria: characterization of an underrecognized phenomenon in a proof-of-concept study.
Authors' conclusion
Discontinuation of MV was associated with a significant increase in urine output.
Study context
- Population
- Adult ICU patients on invasive mechanical ventilation (MV) for 1 to 15 days, extubated to conventional oxygen therapy, CASMU Medical Center (Uruguay)
- Participants
- 60 patients
- Exposure
- Urine output 48 h after vs 48 h before extubation
- Outcome
- Change in urine output following extubation
- Follow-up
- 48 h before and after extubation
Methodological detailsproof-of-concept, single-centre
- Proof-of-concept
- Single-centre
Main finding
As reported in the abstract
Diuresis
P < 0.001
Observational data: associations, not effects.
Further findings
Polyuria (diuresis >3 L in 24 h)
P < 0.001
Duration of elevated urine output
- Urine output (vs pre-extubation) significantly elevated for up to 30 h after extubation
Correlation of diuresis increase with PEEP during MV
- Spearman rs
- 0.368
- P
- P = 0.004
Safety
- Increased diuresis not associated with hemodynamic or renal function impairment
Original publication
Post-extubation polyuria: characterization of an underrecognized phenomenon in a proof-of-concept study. J Crit Care. Published 3 June 2025. doi:10.
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