Predicted effect-site concentrations of remimazolam for i-gel insertion: a prospective randomized controlled study
An erratum to this article was published (J Clin Monit Comput, Dec 2024 ↗)
Authors' conclusion
An effect-site concentration of ≥ 1.57 µg/ml was needed to insert an i-gel using remimazolam anesthesia, even with 2 µg/kg fentanyl.
Study context
- Population
- Patients (38 ± 5 years, male/female = 4/26) undergoing i-gel insertion under remimazolam with fentanyl
- Participants
- Thirty patients
- Comparison
- Five remimazolam doses with fentanyl 2 µg/kg for i-gel insertion
- 0.1n = six
- 0.15n = six
- 0.2n = six
- 0.25n = six
- 0.3n = six
- Primary endpoint
- EC50 and EC95 of remimazolam effect-site concentration for successful i-gel insertion
- Follow-up
- 10 min
Methodological detailsprospective, dose-finding, probit analysis
- Prospective
- Dose-finding
- Probit analysis
Primary result
As reported in the abstract
Remimazolam effect-site concentration for successful i-gel insertion
EC50 (95% CI 0.65-1.11), µg/ml
0.88
EC95 (95% CI 1.09-2.05), µg/ml
1.57
Further findings
| Outcome | Values |
|---|---|
| Successful i-gel insertion per dose groupOf six per group | 0.1 two events · 0.15 two events · 0.2 four events · 0.25 five events · 0.3 six events |
Safety
| Outcome | Values |
|---|---|
| Consciousness at i-gel insertionCounted as failures | 0.1 Two events |
Original publication
Predicted effect-site concentrations of remimazolam for i-gel insertion: a prospective randomized controlled study. J Clin Monit Comput. Published 5 March 2024. doi:10.
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