Anaesthetic drugs & techniques
Remimazolam dose for successful insertion of a supraglottic airway device with opioids: a dose-determination study using Dixon’s up-and-down method
Authors' conclusion
In 95% of nonparalyzed female patients undergoing hysteroscopy, 10.7 mg·kg-1·hr-1 of remimazolam with 1 μg·kg-1 of fentanyl facilitates i-gel insertion. Remimazolam showed a high incidence of poor jaw relaxation and bucking or other movements during SGD insertion.
Study context
- Population
- ASA I–II female patients scheduled for hysteroscopic surgery, induction with fentanyl 1 μg·kg-1 and remimazolam infusion without NMB28 analysed
- Participants
- 30 patients
- Exposure
- Success vs Failure
- Successn = 13
- Failuren = 15reference
- Outcome
- ED50 and ED95 of remimazolam for SGA (i-gel) insertion in nonparalyzed patients
- Follow-up
- 2.5 min after start of remimazolam infusion
Methodological detailsprospective, Dixon's up-and-down method, isotonic regression
- Prospective
- Dixon's up-and-down method
- Isotonic regression
Main finding
As reported in the abstract
Remimazolam dose for successful i-gel insertion
ED50 8.8 mg·kg-1·hr-1
8.8
95% CI 6.3 to 10.6
ED95 10.7 mg·kg-1·hr-1
10.7
95% CI 10.6 to 11.7
Observational data: associations, not effects.
Further findings
| Outcome | Success | Failure | Difference in proportions (95% CI) | P value | |
|---|---|---|---|---|---|
| Nonfully relaxed jaw | 54% | 93% | 40% (7–65) | P = 0.02 | |
| −50050100Difference (linear scale) |
Safety
| Outcome | Failure |
|---|---|
| Bucking or other movements during SGA insertion | 73% |
Bucking or other movements during SGA insertion
- Occurred only in the failure group
Original publication
Remimazolam dose for successful insertion of a supraglottic airway device with opioids: a dose-determination study using Dixon’s up-and-down method. Can J Anaesth. Published 19 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →