Cardiothoracic & vascular anesthesia
Predicting post-cardiac surgery vasopressor use in a large, multicenter national cardiac surgical database
Authors' conclusion
Post-cardiac surgery vasopressor administration can only be predicted with poor to fair accuracy based on patient and surgical variables alone. Significant institutional variation in the rate of vasopressor administration exists, seemingly unrelated to measured patient and surgical factors, and predictive ability improves substantially when this is considered.
Study context
- Population
- Patients who underwent cardiac surgery with CPB, 2012–2021
- Participants
- 106,348 patients · 33 hospitals
- Exposure
- Preoperative model vs Postoperative model
- Outcome
- Postoperative vasopressor administration
Methodological detailsmulticentre, development and validation sets, LASSO models, mixed effects multilevel modeling
- Multicentre
- Development and validation sets
- LASSO models
- Mixed effects multilevel modeling
Main finding
As reported in the abstract
| Group | AUC, fixed effects | AUC, mixed effects (hospital) |
|---|---|---|
| Preoperative model | 0.56 | 0.75 |
| Postoperative model | 0.60 | 0.76 |
AUC, fixed effects
Preoperative model0.56
Postoperative model0.60
AUC, mixed effects (hospital)
Preoperative model0.75
Postoperative model0.76
- Incidence of postoperative vasopressor administration
- 29.3% (n = 31,157)
- Interhospital rate range (median 22.3%)
- 1.20% to 69.4%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Predicting post-cardiac surgery vasopressor use in a large, multicenter national cardiac surgical database. J Cardiothorac Vasc Anesth. Published 3 September 2025. doi:10.
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