Cardiothoracic & vascular anesthesia
Predictive value of early postoperative copeptin after cardiac surgery: A two-centre prospective cohort study
Main finding · New-onset disabilityResult — go to the resultAdjusted odds ratio 2.35 95% CI 1.17–4.72Authors' conclusion
Early postoperative copeptin is independently associated with new-onset disability at 1 year after cardiac surgery.
Study context
- Population
- Adults undergoing elective on-pump cardiac surgery, two German tertiary centres, March 2021–August 2022295 analysed
- Participants
- 363 adults
- Exposure
- Elevated vs non-elevated early postoperative copeptin
- Outcome
- New-onset disability (WHODAS 2.0 score ≥16% or increase ≥5% if pre-operative disability)
- Follow-up
- 1 year
Methodological detailsobservational, multicentre (two German tertiary centres)
- Observational
- Multicentre (two German tertiary centres)
Main finding
New-onset disability
Adjusted odds ratio
2.35
95% CI 1.17–4.72
Elevated vs non-elevated early postoperative copeptin
aOR 2.35 (95% CI 1.17–4.72)
As reported in the abstract
- New-onset disability, overall cohort
- 54 (18.3%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Discrimination for new-onset disability (ROC AUC) · 1 yearEuroSCORE II+troponin+copeptin vs EuroSCORE II+troponin · weak discrimination; no improvement in risk stratification | P = 0.82 |
- Discrimination for new-onset disability (ROC AUC) — AUC EuroSCORE II+troponin+copeptin
- 0.685 (95% CI 0.61 to 0.76)
- Discrimination for new-onset disability (ROC AUC) — AUC EuroSCORE II+troponin
- 0.678 (95% CI 0.59 to 0.76)
Mortality, overall cohort · 1 year
- Died within 1 year
- 3.4% (10/295)
Original publication
Predictive value of early postoperative copeptin after cardiac surgery: A two-centre prospective cohort study. Eur J Anaesthesiol. Published 1 August 2025. doi:10.
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