Respiratory failure & ventilation
Predictors of Noninvasive Ventilation Failure in the Post-Extubation Period: A Systematic Review and Meta-Analysis*
Authors' conclusion
We identified several prognostic factors before and 1 hour after NIV initiation associated with increased risk of NIV failure in the post-extubation period.
Study context
- Population
- Patients receiving noninvasive ventilation (NIV) in the post-extubation period
- Participants
- 2,327 patients · 25 studies
- Comparison
- Prognostic factors for post-extubation NIV failure
- Outcome
- Post-extubation NIV failure necessitating reintubation
Methodological detailsrandom-effects model, QUIPS risk of bias, GRADE certainty
- Random-effects model
- QUIPS risk of bias
- GRADE certainty
Pooled result
As reported in the abstract
Predictors of post-extubation NIV failure necessitating reintubation
Odds ratio (95% CI)
Higher critical illness severityhigh certainty
3.56(1.96–6.45)
Diagnosis of pneumoniamoderate certainty
6.16(2.59–14.66)
Elevated BMImoderate certainty; may be protective
0.21(0.09–0.52)
MD (95% CI)
Higher respiratory rate 1-hour after NIV initiationmoderate certainty
1.54(0.61–2.47)
Higher heart rate 1-hour after NIV initiationmoderate certainty
4.46(1.67–7.25)
Lower Pa o2 :F io2 1-hour after NIV initiationmoderate certainty
−30.78(−50.02 to −11.54)
Higher rapid shallow breathing index prior to NIV startmoderate certainty
15.21(12.04–18.38)
Original publication
Predictors of Noninvasive Ventilation Failure in the Post-Extubation Period: A Systematic Review and Meta-Analysis*. Crit Care Med. Published 30 March 2023. doi:10.
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