Cardiothoracic & vascular anesthesia
Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study
Authors' conclusion
The preoperative peak amplitude of endothelium-dependent vasodilation is independently associated with the postoperative occurrence of AKI.
Study context
- Population
- Patients scheduled for valvular or coronary surgery using cardiopulmonary bypass (CPB), University Hospital of Angers, France30 valvular, 30 coronary
- Participants
- 60 patients
- Comparison
- Acute kidney injury (AKI) vs No AKI
- AKIn = 43
- Primary endpoint
- Occurrence of AKI (KDIGO classification)
- Follow-up
- During the hospital stay
Methodological detailspilot study, single-centre
- Pilot study
- Single-centre
Primary result
As reported in the abstract
AKI (KDIGO) during in-hospital follow-up
AKI
43
71.7%
KDIGO stage 1
15
25%
KDIGO stage 2
20
33%
KDIGO stage 3
8
13%
Further findings
Peak amplitude of vasodilation to ACh iontophoresis (endothelium-dependent) · preoperative
P = 0.04
Response to SNP iontophoresis (endothelium-independent) · preoperative · not significantly different
P = 0.95
Preoperative peak amplitude at acetylcholine (ACh) iontophoresis and postoperative AKI (multivariable model)
| OR (CI) | P value | ||
|---|---|---|---|
| Peak amplitude at ACh iontophoresisIndependently associated · multivariable model | 1.045 (1.001–1.092) | P = 0.045 | |
| 0.512Odds ratio (log scale) |
Original publication
Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study. Perioper Med (Lond). Published 29 February 2024. doi:10.
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