Hemodynamics, fluids & transfusion
Prognostic performance of the ratio of mean arterial pressure to norepinephrine equivalent dose in critically ill hypotensive patients: A single-center retrospective cohort study
Main finding · Hospital mortalityResult — go to the resultAdjusted odds ratio 0.60 95% CI 0.38–0.92Authors' conclusion
In adult patients receiving vasopressor infusion, the lowest MAP/NED ratio within 24 h of ICU admission was independently associated with hospital mortality. Its prognostic discrimination was slightly higher than that of the lowest MAP value and comparable to that of the highest NED.
Study context
- Population
- Adult critically ill hypotensive patients receiving norepinephrine ≥5 μg/min within the first 24 h of intensive care unit (ICU) stay
- Participants
- 937 patients
- Exposure
- Lowest mean arterial pressure (MAP)/norepinephrine equivalent dose (NED) ratio vs lowest MAP and highest NED as predictors of hospital mortality
- Outcome
- Hospital mortality
Methodological detailssingle-centre, consecutive inclusion
- Single-centre
- Consecutive inclusion
Main finding
As reported in the abstract
Adjusted odds ratio
0.60
95% CI 0.38–0.92
By group
Lowest MAP/NED ratio
0.625
AUC
Lowest MAP
0.562
AUC
Highest NED
0.625
AUC
Highest tertile of lowest MAP/NED ratio vs Lowest tertile
aOR 0.60 (95% CI 0.38–0.92)
- Overall hospital mortality
- 29%
Observational data: associations, not effects.
Original publication
Prognostic performance of the ratio of mean arterial pressure to norepinephrine equivalent dose in critically ill hypotensive patients: A single-center retrospective cohort study. J Crit Care. Published 7 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →