Cardiothoracic & vascular anesthesia
Prognostic value of venous-to-arterial pCO2 gap during cardiopulmonary bypass for predicting cardiac surgery-associated kidney injury: A bicentric retrospective study
Authors' conclusion
We did not find any association between the presence of an elevated pCO2 gap during CPB and the occurrence of CSA-AKI.
Study context
- Population
- Patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB) in two teaching hospitals, two periods between 2019 and 2023
- Participants
- 318 patients
- Exposure
- Elevated vs low central venous-to-arterial pCO2 gap during CPB
- Low pCO2 gapn = 213reference
- Elevated pCO2 gapn = 105
- Outcome
- Occurrence of cardiac surgery-associated AKI (CSA-AKI)
Methodological detailsbicentric
- Bicentric
Main finding
As reported in the abstract
CSA-AKI occurrence
- No significant difference in cardiac surgery-associated acute kidney injury (CSA-AKI) occurrence between groups (32.4% vs. 23.8%; p = 0.14)
Observational data: associations, not effects.
Further findings
pCO2 gap as predictor of CSA-AKI
- AUC (ROC); not a good predictor
- 0.63
- p = 0.87
Correlation of pCO2 gap with other tissue perfusion parameters during or after CPB
- No correlation found, except with SVO2 during CPB
Original publication
Prognostic value of venous-to-arterial pCO2 gap during cardiopulmonary bypass for predicting cardiac surgery-associated kidney injury: A bicentric retrospective study. Anaesth Crit Care Pain Med. Published 7 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →