Respiratory failure & ventilation
Prognostic value of oxygen saturation index trajectory phenotypes on intensive care unit (ICU) mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Authors' conclusion
Dynamic OSI-trajectory phenotypes were closely related to the mortality of ICU patients requiring IMV treatment and might be a useful prognostic indicator in critically ill patients.
Study context
- Population
- Critically ill patients undergoing invasive mechanical ventilation (IMV)
- Participants
- 3,378 patients
- Exposure
- Oxygen saturation index (OSI)-trajectory phenotypes: high-level stable, ascending, descending vs low-level stable
- Outcome
- ICU mortality
Methodological detailsmulti-database, group-based trajectory model, doubly robust analysis
- Multi-database
- Group-based trajectory model
- Doubly robust analysis
Main finding
As reported in the abstract
Odds ratio (95% CI)
High-level stable vs Low-level stable
1.422(1.246–1.623)
Ascending vs Low-level stable
1.097(1.027–1.172)
Descending vs Low-level stablesimilar ICU mortality to low-level stable
0.986(0.940–1.035)
Observational data: associations, not effects.
Further findings
Mortality and ventilation-free days (VFDs) by phenotype
- High-level stable phenotype had the highest mortality and fewest VFDs
Predictive model for ascending or high-level stable phenotypes (early identification)
- AUC, training dataset
- 0.851 [0.827-0.875]
- AUC, validation dataset
- 0.743 [0.709-0.777]
Original publication
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study. J Intensive Care. Published 29 November 2023. doi:10.
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