Respiratory failure & ventilation
Progressive changes in pulmonary gas exchange during invasive respiratory support for COVID‐19 associated acute respiratory failure: A retrospective study of the association with 90‐day mortality
Authors' conclusion
The progressive changes in P/F ratio and Vd/Vt in the first 2 weeks of invasive ventilatory support for COVID-19 ARDS were significant predictors for 90-day mortality.
Study context
- Population
- Patients with COVID-19 associated ARDS admitted to the Intensive Care Unit (ICU) for invasive ventilatory supportalmost 20,000 blood gases
- Participants
- 130 patients
- Outcome
- Predictive value of P/F ratio and Vd/Vt for mortality (adjusted HR, Cox proportional hazard regression)
- Follow-up
- 90 days
Methodological detailssingle-centre, observational, P/F ratios and Vd/Vt assessed up to 4 weeks after ICU admission; first 2 weeks used for prediction
- Single-centre
- Observational
- P/F ratios and Vd/Vt assessed up to 4 weeks after ICU admission; first 2 weeks used for prediction
Main finding
As reported in the abstract
90-day mortality by P/F ratio and Vd/Vt, first ICU week · first ICU week
Hazard ratio (CI)
Every 10 mmHg increase in P/F ratio
0.85(0.77–0.94)
Every 0.1 increase in Vd/Vt
1.61(1.20–2.16)
Each row per its own increment, as printed
- Overall 90-day mortality
- 30%
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| 90-day mortality by P/F ratio and Vd/Vt, second ICU weekEvery 10 mmHg increase in P/F ratio · adjusted | 0.82 (0.75–0.89) | |
| 90-day mortality by P/F ratio and Vd/Vt, second ICU weekEvery 0.1 increase in Vd/Vt · adjusted | 1.97 (1.42–2.73) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Progressive changes in pulmonary gas exchange during invasive respiratory support for COVID‐19 associated acute respiratory failure: A retrospective study of the association with 90‐day mortality. Acta Anaesthesiol Scand. Published 2 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →