Respiratory failure & ventilation
Prolonged Prone Position Ventilation Is Associated With Reduced Mortality in Intubated COVID-19 Patients
Main finding · 30-day all-cause mortalityResult — go to the resultAdjusted hazard ratio 0.475 95% CI 0.336–0.670Authors' conclusion
Among intubated COVID-19 patients who received PPV, prolonged PPV was associated with reduced mortality.
Study context
- Population
- Consecutively admitted intubated COVID-19 patients treated with PPV, March 11–May 31, 2020
- Participants
- 157 vs 110
- Exposure
- Prolonged vs intermittent prone position ventilation
- Prolonged PPVn = 157
- Intermittent PPVn = 110reference
- Outcome
- 30-day all-cause mortality
- Follow-up
- 30 days
Methodological detailsmulticentre, inverse probability treatment weighting
- Multicentre
- Inverse probability treatment weighting
Main finding
As reported in the abstract
Adjusted hazard ratio
0.475
95% CI 0.336–0.670
P < 0.001
Prolonged PPV vs Intermittent PPV
aHR 0.475 (95% CI 0.336–0.670); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| 90-day all-cause mortality | 0.638 (0.461–0.883) | P = 0.006 | |
| 30-day mortality (subgroup PaO2/FiO2 ≤ 150 at pronation) | 0.357 (0.213–0.597) | P < 0.001 | |
| 90-day mortality (subgroup PaO2/FiO2 ≤ 150 at pronation) | 0.562 (0.357–0.884) | P = 0.008 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Median
| Outcome | Prolonged PPV | Intermittent PPV | P value |
|---|---|---|---|
| Pronation and supination events | 1 (95% CI 1–2) | 3 (95% CI 1–4) | P < 0.001 |
Safety
- PPV strategy not associated with overall PPV-related complications
- Prolonged PPV: increased facial edema, lower peri-proning hypotension
Original publication
Prolonged Prone Position Ventilation Is Associated With Reduced Mortality in Intubated COVID-19 Patients. Chest. Published 4 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →