Cardiothoracic & vascular anesthesia
Prolonged Systemic Inflammatory Response Syndrome After Cardiac Surgery
Authors' conclusion
Nerve growth factor and interleukin 5 can be used to predict prolonged systemic inflammatory response, which is associated with POAF, stroke, and mortality.
Study context
- Population
- Volunteer patients undergoing cardiac surgery with CPB, followed up to 90 daysvolunteer cohort
- Participants
- 261 patients
- Exposure
- Prolonged systemic inflammatory response syndrome (SIRS) vs no prolonged SIRS after cardiac surgery
- Prolonged SIRSn = 17
- Outcome
- Prolonged SIRS as predictor of postoperative outcomes
Methodological detailssingle-centre, prospectively enrolled
- Single-centre
- Prospectively enrolled
Main finding
As reported in the abstract
Prolonged SIRS
6.4%
17
Prolonged SIRS vs No prolonged SIRSOdds ratio (95% CI)
POAF
4.5(1.2–17.3)
90-day stroke
4.5(1.1–18.0)
Mortality
10.7(1.7–68.8)
- Postoperative atrial fibrillation (POAF) during hospitalisation, all patients
- 42.2%
- Stroke and transient ischemic attack during hospitalisation, all patients
- 3.8%
Observational data: associations, not effects.
Further findings
Preoperative biomarkers associated with prolonged SIRS
| OR (95% CI) | ||
|---|---|---|
| Nerve growth factor | 5.6 (1.4–23.2) | |
| Interleukin 5 | 0.7 (0.4–1.0) | |
| 0.050.21520Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prolonged Systemic Inflammatory Response Syndrome After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 18 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →