Cardiothoracic & vascular anaesthesia
The Relationship Between the Preoperative Gut Microbiome and Systemic Inflammatory Response Syndrome After Cardiac Surgery: A Prospective Cohort Study
Authors' conclusion
In this cohort of elective cardiac surgery patients, preoperative gut microbiome diversity, composition, and functional potential were not associated with the development of postoperative SIRS.
Study context
- Population
- Adults undergoing elective cardiac surgery with extracorporeal circulation, tertiary university hospital, 2018–2019
- Participants
- 196 adults
- Exposure
- Systemic inflammatory response syndrome (SIRS) vs non-SIRS
- SIRSn = 44
- Outcome
- Development of SIRS
- Follow-up
- 24 hours postoperatively
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
SIRS incidence
Patients who developed SIRS
44
22%
Observational data: associations, not effects.
Further findings
Diversity and SIRS risk (adjusted for age and sex)
| OR (95% CI) | ||
|---|---|---|
| DiversityAdjusted for age and sex | 1.04 (0.99–1.07) | |
| 0.512Odds ratio (log scale) |
Median
| Outcome | SIRS | non-SIRS | P value |
|---|---|---|---|
| Microbiome diversity (inverse Simpson index) | 20.4 | 19.3 | P = 0.12 |
- Microbiome diversity (inverse Simpson index) — Gene richness did not differ
- p = 0.30
- Microbiome diversity (inverse Simpson index) — Dominance did not differ
- p = 0.61
Taxonomic composition and functional potential
- No significant differences between SIRS and non-SIRS groups
Original publication
The Relationship Between the Preoperative Gut Microbiome and Systemic Inflammatory Response Syndrome After Cardiac Surgery: A Prospective Cohort Study. J Cardiothorac Vasc Anesth. Published 13 August 2026. doi:10.
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