Cardiothoracic & vascular anesthesia
Prophylactic Intravenous Tranexamic Acid in Thoracic Surgery: A Matched-pair Analysis From the German Thoracic Registry
Authors' conclusion
Prophylactic intravenous TXA did not reduce bleeding complications in thoracic surgery but was associated with a lower incidence of thromboembolic and cardiac events.
Study context
- Population
- Adults undergoing thoracic surgical procedures, German Thorax Registry, multiple centresmatched 1:1
- Participants
- 1,034 adults
- Exposure
- Prophylactic IV tranexamic acid (TXA) vs no TXA before thoracic surgery
- TXAn = 517
- No TXAn = 517reference
- Outcome
- Postoperative bleeding complications, including reoperations for bleeding and transfusion requirements
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Postoperative bleeding complications (reoperation for bleeding, transfusion)
- No significant difference between groups
- Matched cohort
Observational data: associations, not effects.
Further findings
Cardiac complications
- Less frequent in the TXA group
Overall complications and hospital LOS
- No significant differences
Safety
Thromboembolic complications
Thromboembolic complications
- Significantly less frequent in the TXA group
Original publication
Prophylactic Intravenous Tranexamic Acid in Thoracic Surgery: A Matched-pair Analysis From the German Thoracic Registry. J Cardiothorac Vasc Anesth. Published 4 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →