Respiratory failure & ventilation
Rapid non-invasive measurement of mitochondrial oxygen tension after microneedle pre-treatment: a feasibility study in human volunteers
Authors' conclusion
We demonstrate that pre-treatment with microneedling before topical application of 5-aminolevulinic acid enables obtaining a reliable and accurate mitoPO2 signal at least an hour faster than on untreated skin in our population of human volunteers.
Study context
- Population
- Healthy human volunteers
- Participants
- 9 volunteers
- Comparison
- Microneedled vs Untreated
- Outcome
- Time-to-sufficient mitoPO2 signal after topical ALA administration
Methodological detailswithin-subject comparison, mitoPO2 varied using different FiO2 after induction
- Within-subject comparison
- mitoPO2 varied using different FiO2 after induction
Main finding
As reported in the abstract
Time to reliable signal after topical ALA
P = 0.02
Further findings
| Outcome | Estimate |
|---|---|
| Agreement of mitoPO2 between microneedling and untreated skinMicroneedling vs Untreated | intraclass correlation 0.892 (95% CI 0.821–0.936) |
| Agreement of mitoVO2 between microneedling and untreated skinMicroneedling vs Untreated · poor agreement | ICC 0.316 (CI 0.04–0.55) |
Original publication
Rapid non-invasive measurement of mitochondrial oxygen tension after microneedle pre-treatment: a feasibility study in human volunteers. J Clin Monit Comput. Published 26 December 2024. doi:10.
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