Cardiothoracic & vascular anesthesia
Real-Time Individualization of Unfractionated Heparin (UFH) Dosing in Cardiac Procedures: Development and Validation of an Online ACT-Based Target-Controlled Tool
Main finding · ACT variabilityResult — go to the resultVariance ratio 2.3Authors' conclusion
The real-time individualized UFH dosing algorithm was associated with improved control of ACT values and reduced variability during cardiac procedures in this retrospective analysis.
Study context
- Population
- Adults undergoing cardiac surgery with or without cardiopulmonary bypass (CPB)446 development, 105 validation
- Participants
- 83 vs 83
- Exposure
- Individualized dosing vs Controls
- Individualized dosingn = 83
- Controlsn = 83reference
- Outcome
- ACT variability
Methodological detailsmodel development and external validation, matched historical controls, multiinstitutional external validation
- Model development and external validation
- Matched historical controls
- Multiinstitutional external validation
Main finding
As reported in the abstract
Variance ratio
2.3
P < 0.001
Observational data: associations, not effects.
Further findings
Model predictive performance
- Strong predictive performance; bias and mean absolute error decreased as additional activated clotting time (ACT) measurements were incorporated
- Development 446 patients (2,534 ACT measurements); external validation 105 patients
Original publication
Real-Time Individualization of UFH Dosing in Cardiac Procedures: Development and Validation of an Online ACT-Based Target-Controlled Tool. J Cardiothorac Vasc Anesth. Published 3 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →