Cardiothoracic & vascular anesthesia
Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial
Authors' conclusion
This study showed that a target ACT of ≥400 seconds is equivalent to a target ACT of ≥480 seconds in terms of intraoperative and postoperative PRBC transfusion rates in the modern cardiac surgery setting.
Study context
- Population
- Adults ≥18 years scheduled for first-time elective cardiac surgery with cardiopulmonary bypass (CPB), tertiary and university medical centres in the Netherlands, November 2019 to December 2023
- Participants
- 1,021 adults
- Comparison
- Lower target activated clotting time (ACT) ≥400 seconds vs higher target ACT ≥480 seconds
- Primary endpoint
- PRBC transfusion
Methodological detailsmulticentre, single-blind, equivalence
- Multicentre
- Single-blind
- Equivalence
Primary result
As reported in the abstract
Packed red blood cell (PRBC) transfusion equivalent in both ACT groups
19.1% v 17.2%
Risk difference (as printed)
−0.029; 0.066
Secondary outcomes
Blood loss · 6 hours postoperative · lacking clinical relevance
P = 0.003
Blood loss · 24 hours postoperative · lacking clinical relevance
P = 0.007
Hemoglobin · 6 hours after surgery · lacking clinical relevance
P = 0.017
Hemoglobin · 1 day after surgery · lacking clinical relevance
P = 0.045
Safety
Thromboembolic events
- Frequency similar in both groups
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →