Respiratory failure & ventilation
A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study
An erratum to this article was published (Intensive Care Med, Nov 2025 ↗)
Main finding · 30-day hospital mortalityResult — go to the resultHazard ratio 2.00 95% CI 1.23–3.26Authors' conclusion
VAEs were associated with an increased risk of mortality after adjustment for severity, as a time-dependent confounder.
Study context
- Population
- Patients aged ≥ 12 years receiving mechanical ventilation for ≥ 3 consecutive days in 18 ICUs in Japan, May 2020–December 2022
- Participants
- 1,094 patients · 18 ICUs
- Exposure
- VAE vs no VAE
- VAEn = 106
- Outcome
- In-hospital mortality
- Follow-up
- 30 days
Methodological detailsmarginal structural model, inverse probability weighted proportional hazards model, time-dependent confounders
- Marginal structural model
- Inverse probability weighted proportional hazards model
- Time-dependent confounders
Main finding
30-day hospital mortality
Hazard ratio
2.00
95% CI 1.23–3.26
VAE vs No VAE
HR 2.00 (95% CI 1.23–3.26)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| 30-day ICU mortality | 1.92 (1.03–3.57) | |
| Hospital LOSLonger LOS | 0.72 (0.54–0.97) | |
| ICU LOSLonger LOS | 0.47 (0.23–0.96) | |
| 0.20.5125Hazard ratio (log scale) |
- VAE incidence
- 9.7% · 106
Population attributable risk fraction of VAE-related mortality
- In-hospital deaths
- 8.8%
- ICU deaths
- 8.2%
Original publication
A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study. Intensive Care Med. Published 1 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →