Anesthetic drugs & techniques

Remimazolam for sedation: A protocol for a systematic review with meta‐analysis, trial sequential analysis, and GRADE approach

Acta Anaesthesiol ScandPublished Protocol for a systematic review and meta-analysis of randomised trials

Study context

Population
Adults requiring sedation for a diagnostic or therapeutic procedure, or due to other circumstances
Planned comparison
Remimazolam vs placebo or other sedatives
Primary endpoint
Sedation success rate, respiratory complications, and hemodynamic complications
Methodological detailstrial sequential analysis, GRADE approach, PRISMA, Risk of bias assessed with Risk of Bias 2 Tool; random error with trial sequential analysis; certainty of evidence with GRADE
  • Trial sequential analysis
  • GRADE approach
  • PRISMA
  • Risk of bias assessed with Risk of Bias 2 Tool; random error with trial sequential analysis; certainty of evidence with GRADE

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Remimazolam for sedation: A protocol for a systematic review with meta‐analysis, trial sequential analysis, and GRADE approach. Acta Anaesthesiol Scand. Published 14 August 2023. doi:10.1111/aas.14316

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