Cardiothoracic & vascular anesthesia
Renal tubular epithelial cells as an easily accessible biomarker for diagnosing acute kidney injury (AKI) post cardiac surgery
Authors' conclusion
Urinary particle analysis with RTEC is useful for the early diagnosis of AKI following cardiac surgery, especially at 12 h and 24 h after ICU admission.
Study context
- Population
- Adults after cardiac surgery admitted to intensive care unit (ICU)
- Participants
- 239 adults
- Comparison
- Urinary particle analysis (renal tubular epithelial cells (RTEC), non-hyaline casts) vs Nephrocheck®, urinary alpha-1-microglobulin and urinary GGT for AKI diagnosis
- Outcome
- AKI stage ≥ 1 (KDIGO)
- Follow-up
- Within 48 h after ICU admission
Performance
As reported in the abstract
AKI stage ≥ 1 within 48 h · early postoperative period
- Urinary alpha-1-microglobulin was a good predictor of AKI stage ≥ 1 within 48 h
Secondary outcomes
AKI incidence by stage
- AKI stage 1
- 39 (16.3%)
- AKI stage 2
- 121 (50.6%)
- AKI stage 3
- 15 (6.3%)
AKI stage ≥ 2 (1st secondary endpoint) · early postoperative period
- Nephrocheck® was a good predictor of AKI stage ≥ 2
AKI up to 48 h (serum creatinine alone) and all AKI criteria up to 7 days · 12 h and 24 h after ICU admission
- RTEC had the highest predictive value
Correction of counts for hydration status
- Did not improve the results
Original publication
Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery. Intensive Care Med. Published 5 May 2025. doi:10.
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