Reproducibility of glycocheck measurements in patients under general anesthesia with muscle relaxants: A prospective observational study
Authors' conclusion
In patients under general anesthesia, single PBR, VD, and RBCF measurements using the GlycoCheck system showed poor interobserver reproducibility.
Study context
- Population
- Patients under GA with muscle relaxants for laparoscopic gastrointestinal surgery
- Participants
- 50 participants
- Outcome
- Inter- and intraobserver reproducibility (ICC) of sublingual microcirculatory indices (PBR, VD, RBCF) measured with the GlycoCheck system
- Follow-up
- After induction of GA
Methodological detailsreproducibility study, Leading observer took two and one of five subobservers took one measurement per patient
- Reproducibility study
- Leading observer took two and one of five subobservers took one measurement per patient
Main finding
As reported in the abstract
Inter- and intraobserver ICC
- Interobserver intraclass correlation coefficients (ICC), perfused boundary region (PBR)
- 0.13 (95% CI −0.15, 0.39)
- Interobserver ICC, vascular density (VD) (95% CI −0.29, 0.27)
- - 0.01
- Interobserver ICC, red blood cell filling (RBCF)
- 0.31 (95% CI −0.45, 0.78)
- Intraobserver ICC, PBR, all 50 cases
- 0.32 (95% CI 0.05, 0.55)
- Intraobserver ICC, PBR, first 25 cases
- 0.17 (95% CI −0.25, 0.53)
- Intraobserver ICC, PBR, second 25 cases
- 0.46 (95% CI 0.09, 0.72)
Observational data: associations, not effects.
Further findings
Bland-Altman analysis
- Measurement errors were random
Original publication
Reproducibility of glycocheck measurements in patients under general anesthesia with muscle relaxants: A prospective observational study. J Clin Monit Comput. Published 10 July 2025. doi:10.
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