Cardiothoracic & vascular anesthesia
Role of del Nido Cardioplegia Solution in Prolonged Aortic Cross-clamp Cardiac Surgery: A Prospective Study
Authors' conclusion
The incidence of postoperative atrial fibrillation at 48 hours was significantly lower in the del Nido group than in the Buckberg group.
Study context
- Population
- Adults scheduled for cardiac surgery under CPB with expected aortic cross-clamp time >120 minutes, January 2020 to January 2024enrolled
- Participants
- 462 adults
- Exposure
- Del Nido vs Buckberg cardioplegia, in low- and high-risk patients
- Low-risk del Nidon = 112
- Low-risk Buckbergn = 112reference
- High-risk del Nidon = 112
- High-risk Buckbergn = 112reference
- Outcome
- Cardiac troponin T and creatine kinase-MB
- Follow-up
- 1, 24 and 48 hours postoperatively
Methodological detailssingle-centre, random assignment, tertiary academic medical centre
- Single-centre
- Random assignment
- Tertiary academic medical centre
Main finding
As reported in the abstract
- No significant differences in troponin T or creatine kinase-MB at the other time points
- Low-risk del Nido vs Low-risk Buckberg: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Postoperative AF · 48 hoursLow-risk Buckberg vs Low-risk del Nido · incidence significantly higher with Buckberg | P < 0.05 |
| Postoperative AF · 48 hoursHigh-risk Buckberg vs High-risk del Nido · incidence significantly higher with Buckberg | P < 0.05 |
Original publication
Role of del Nido Cardioplegia Solution in Prolonged Aortic Cross-clamp Cardiac Surgery: A Prospective Study. J Cardiothorac Vasc Anesth. Published 7 December 2024. doi:10.
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