Cardiothoracic & vascular anesthesia
Del Nido Cardioplegia in Adult Cardiac Surgery: Meta-Analysis of Randomized Clinical Trials
Pooled result · Postoperative stroke and/or transient ischemic attackResult — go to the resultOdds ratio 0.43 95% CI 0.20–0.92Authors' conclusion
According to the authors' meta-analysis of recent randomized clinical trials, del Nido is a safe cardioplegic solution, which might provide better organ protection in adult cardiac surgery without differences in mortality when compared to other cardioplegic solutions.
Study context
- Population
- Adults (≥18 years old) undergoing cardiac surgery
- Participants
- 1,812 adults · 10 RCTs
- Comparison
- Del Nido cardioplegia vs any other cardioplegia
- Del Nidon = 871
- Controln = 941reference
- Outcome
- Postoperative stroke and/or transient ischemic attack
Pooled result
As reported in the abstract
Odds ratio
0.43
95% CI 0.20–0.92
P = 0.007
Events by group
Del Nido vs Control
OR 0.43 (95% CI 0.20–0.92); P = 0.007
Further pooled results
| Outcome | Mean difference (minutes) (95% CI) | P value | |
|---|---|---|---|
| Aortic cross-clamp time | −8.99 (−17.24 to −0.73) | P < 0.001 | |
| −20−10010Difference, minutes (linear scale) |
| Outcome | Del Nido | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Need for defibrillation | 15% | 38% | 0.33 (0.15–0.72) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Mortality · no effect on mortality
P = 0.5
Safety
| Outcome | Del Nido | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative AKI | 8.9% | 11% | 0.50 (0.26–0.97) | P = 0.04 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Del Nido Cardioplegia in Adult Cardiac Surgery: Meta-Analysis of Randomized Clinical Trials. J Cardiothorac Vasc Anesth. Published 4 March 2023. doi:10.
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