Cardiothoracic & vascular anesthesia
Propofol-Supplemented Cardioplegic Solution Effect on Myocardial Protection: A Systematic Review and Bayesian Meta-analysis of Randomized Controlled Trials
Authors' conclusion
Current evidence suggests moderate posterior probabilities of benefit across endpoints. However, substantial uncertainty remains regarding the magnitude and direction of the true treatment effects.
Study context
- Population
- Adults undergoing cardiac surgery requiring CPB
- Participants
- 523 adults
- Comparison
- Propofol-supplemented cardioplegic solution vs standard cardioplegia
- Outcome
- Postoperative troponin levels
Methodological detailsBayesian hierarchical random-effects model, weakly informative priors
- Bayesian hierarchical random-effects model
- Weakly informative priors
Pooled result
As reported in the abstract
Pooled SMD, propofol-supplemented vs standard cardioplegia
−0.05
95% CrI −0.33 to 0.24
Posterior probability of any reduction in postoperative troponin (SMD < 0)
70.8%
Further pooled results
Postoperative creatinine levels
- SMD
- −0.06 (95% CrI −0.71 to 0.46)
- Probability of benefit
- 59.8%
Serious complications
- RR
- 0.77 (95% CrI 0.18 to 2.28)
- Probability of benefit
- 70.3%
Postoperative arrhythmias
- RR
- 0.96 (95% CrI 0.51 to 1.62)
- Probability of benefit
- 56.4%
Original publication
Propofol-Supplemented Cardioplegic Solution Effect on Myocardial Protection: A Systematic Review and Bayesian Meta-analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. Published 6 August 2026. doi:10.
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