Cardiothoracic & vascular anesthesia
Role of major cardiovascular surgery-induced metabolic reprogramming in acute kidney injury in critical care
Authors' conclusion
Major cardiovascular surgery, particularly with CPB, induces significant changes in protein metabolism. Patients developing postoperative AKI exhibited specific metabolic signatures.
Study context
- Population
- Patients undergoing major cardiovascular surgery
- Participants
- 53 patients
- Exposure
- Cardiac surgery with CPB vs without CPB vs major vascular surgery
- CPBn = 33
- Without CPBn = 10
- Major vascular surgeryn = 10
- Outcome
- Surgery-induced metabolic changes (serum untargeted metabolomics) and their role in postoperative AKI
- Follow-up
- Pre-surgery, 6 h and 24 h post-surgery
Methodological detailsuntargeted metabolomics, linear mixed-effect models adjusted for age, sex and BMI
- Untargeted metabolomics
- Linear mixed-effect models adjusted for age, sex and BMI
Main finding
As reported in the abstract
Metabolic changes after major cardiovascular surgery · across 3 time points
- CPB: metabolic features significantly altered (P < 2.8E - 05) of 8668 quantified
- 772
Observational data: associations, not effects.
Further findings
Metabolic signature of postoperative acute kidney injury (AKI)
- Patients with postoperative AKI: increased protein catabolism (incl. valine, leucine and isoleucine degradation), citric acid cycle disruption, plasma acylcarnitine accumulation
Original publication
Role of major cardiovascular surgery-induced metabolic reprogramming in acute kidney injury in critical care. Intensive Care Med. Published 27 January 2025. doi:10.
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