Cardiothoracic & vascular anesthesia
Safety and Efficacy of Albumin for Pump Priming in Cardiac Surgery: A Meta-Analysis
Authors' conclusion
Albumin was shown to be safe and efficacious in extracorporeal circulation perfusion. However, its clinical advantages were not clearly highlighted, as there were no significant differences in the number of deaths, length of hospital stay, or intensive care unit duration.
Study context
- Population
- Adult and pediatric patients undergoing cardiac surgery with CPB who received circuit priming fluids
- Participants
- 741 participants · 14 RCTs
- Comparison
- Albumin vs crystalloid for extracorporeal circuit priming
- Outcome
- Bleeding
Pooled result
As reported in the abstract
- Albumin vs Crystalloid: CI −202.20 to −142.88; P < 0.00001
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| Platelet countsGreater preservation with albumin | (CI 14.85–21.48) | P < 0.00001 |
Colloid osmotic pressure and fluid balance
- Albumin better maintained colloid osmotic pressure and sustained negative fluid balance
Deaths, hospital LOS, ICU duration and remaining outcomes
- No significant differences
Original publication
Safety and Efficacy of Albumin for Pump Priming in Cardiac Surgery: A Meta-Analysis. J Cardiothorac Vasc Anesth. Published 4 November 2023. doi:10.
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